Usually they just need time to get used to new surroundings and settle down when they've just been on a car ride. I'd make sure he has plenty of decor to hide in. I'd also keep his tank dimly lit for awhile until he perks up.
If you've got a proper set up: a large enough tank (my general rule is at least 2 gallons, some say 5), enough decor (soft silk plants and caves with no sharp edges) and clean water with adequate water changes, then he just needs time.
Generally they get used to your hand because it is what feeds them. Get him to associate your hand with food. They are curious and will likely check out anything new you add to their tank, including your hand. If he's skittish, just put your fingers in the tank and keep them very still and let him come to you.
Obviously if you've read some posts here, some will never get too close to your hand. Like my VT: he'll circle my hand but will keep a bit of distance from it. He'll get closer if I keep my hand very still.
They also will communicate with you even if your hands are outside the tank. They are very social :)